Disorders of Pigmentation
Identifieur interne : 001729 ( Main/Exploration ); précédent : 001728; suivant : 001730Disorders of Pigmentation
Auteurs : Susanna K. Fistarol [Suisse] ; Peter H. Itin [Suisse]Source :
- JDDG: Journal der Deutschen Dermatologischen Gesellschaft [ 1610-0379 ] ; 2010-03.
English descriptors
- Teeft :
- Abnormal, Abnormal melanogenesis, Abnormal transfer, Acad dermatol, Academy figure, Accurate diagnosis, Acth, Addison, Addison disease, Albinism, Albright syndrome, Algorithm, Anogenital regions, Antwort, Atopic dermatitis, Atrial myxomas, Authors journal compilation blackwell verlag gmbh, Autoimmune disorder, Autosomal, Average risk, Axillary freckling, Basal, Basal cell layer, Basal layer, Bedingt, Beim panhypopituitarismus entsteht, Berlin jddg, Berlin jddg academy, Berlin jddg jddg, Biochemical testing, Blue nevi, Brown color, Brown discoloration, Bullous porphyrias, Caucasian population, Clinical approach, Clinical examination, Congenital, Congenital hypopigmentation, Congenital lesion, Copper metabolism, Cowden syndrome, Crowe sign, Cutaneous, Depigmentation, Depigmented nevi, Depigmentosus, Dermatol, Dermatol clin, Differential diagnosis, Diffuse, Diffuse hyperpigmentation, Diffuse hypopigmentation, Diffuse variant, Dirty skin color, Disorder, Durch, Early childhood, Ectodermal dysplasias, Enzyme tyrosinase, Epidermal, Evidence level, Felty syndrome, First months, First years, Genetic disorder, Genetic mosaicism, Gmbh, Hautfarbe wird vorwiegend durch, Healthy newborns, Histology, Hyperpigmentation, Hypomelanosis, Hypophyseal tumors, Hypopigmentation, Hypopigmentation results, Important factor, Inflammatory skin disease, Iris hamartomas, Jddg, Keratinocytes, Lentigo, Leopard syndrome, Lesion, Leukoderma, Lichen sclerosus, Light hair, Linea alba, Lisch nodules, Localized, Localized depigmentation, Localized hyperpigmentation, Localized hypopigmentation, Lysosomal organelles, Malassezia furfur, Mature melanosomes, Medical history, Melanin, Melanin production, Melanin synthesis, Melanocyte, Melanocytic nevi, Melanoma, Melanosomes, Mucous membranes, Neural crest, Nevus, Nevus anaemicus, Nevus depigmentosus, Nevus depigmentosus simplex, Oral mucosa, Other factors, Other organs, Piebaldism, Pigmentary changes, Pigmentation, Pigmentation disorders, Pityriasis, Pityriasis alba, Pityriasis versicolor, Porphyria, Presumptive diagnosis, Primary biliary cirrhosis, Progressive hypomelanose, Progressive macular hypomelanosis, Proximal extremities, Psychomotor retardation, Renal insufficiency, Rete ridges, Richtig, Sclerosis, Secondary body hair, Segmental vitiligo, Simplex, Skin cancer, Skin color, Stratum corneum, Syndrome, Systemic diseases, Systemic sclerosis, Tuberous, Tuberous sclerosis, Tyrosinase activity, Various ethnicities, Various organs, Various therapies, Verdachtsdiagnose eines morbus addison wird gesichert durch, Verlag, Vitiligo, Vorwiegend, Waardenburg syndrome, Welche, Welche antwort, Wird, Wood light.
Abstract
Skin color is highly individual and the variations are controlled by numerous genes. The different skin colors result from the size and number of melanosomes and do not mirror the amount of melanocytes. Disorders of pigmentation can result from migration abnormalities of melanocytes from the neural crest to the skin during embryogenesis. In addition, impairment of melanosome transfer to the surrounding keratinocytes, an alteration in melanin synthesis and a defective degradation or removal of melanin may lead to abnormal skin pigmentation. Immunologic or toxic mediated destructions of melanocytes can end in pigmentation disorders. Disorders of pigmentation are classified in hypo‐ or hyperpigmentation which can occur as a genetic or acquired disease. They can manifest locally or diffuse. Congenital hypopigmentation can be restricted to the skin as in piebaldism or they represent a systemic disease as in Menkes disease or phenylketonuria. Localized hypo‐ or hyperpigmentation in children may serve as markers for systemic diseases. Ash‐leaf hypopigmentation are characteristic for tuberous sclerosis and more than 5 café‐au‐lait spots suggest neurofibromatosis 1 (von Recklinghausen disease). The most common autoimmune‐induced depigmentation is vitiligo. Generalized hyperpigmentation only rarely reflects a primary genetic disorder but is most often from acquired diseases as in Addison disease, secondary hemochromatosis or primary biliary cirrhosis. Treatment of pigmentation disorders are based on a diagnosis which sometimes allow a specific intervention. Cosmetically acceptable results are difficult to obtain.
Url:
DOI: 10.1111/j.1610-0387.2009.07137.x
Affiliations:
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Le document en format XML
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type="ISSN">1610-0379</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abnormal</term><term>Abnormal melanogenesis</term><term>Abnormal transfer</term><term>Acad dermatol</term><term>Academy figure</term><term>Accurate diagnosis</term><term>Acth</term><term>Addison</term><term>Addison disease</term><term>Albinism</term><term>Albright syndrome</term><term>Algorithm</term><term>Anogenital regions</term><term>Antwort</term><term>Atopic dermatitis</term><term>Atrial myxomas</term><term>Authors journal compilation blackwell verlag gmbh</term><term>Autoimmune disorder</term><term>Autosomal</term><term>Average risk</term><term>Axillary freckling</term><term>Basal</term><term>Basal cell layer</term><term>Basal layer</term><term>Bedingt</term><term>Beim panhypopituitarismus entsteht</term><term>Berlin jddg</term><term>Berlin jddg academy</term><term>Berlin jddg jddg</term><term>Biochemical testing</term><term>Blue nevi</term><term>Brown color</term><term>Brown discoloration</term><term>Bullous porphyrias</term><term>Caucasian population</term><term>Clinical approach</term><term>Clinical examination</term><term>Congenital</term><term>Congenital hypopigmentation</term><term>Congenital lesion</term><term>Copper metabolism</term><term>Cowden syndrome</term><term>Crowe sign</term><term>Cutaneous</term><term>Depigmentation</term><term>Depigmented nevi</term><term>Depigmentosus</term><term>Dermatol</term><term>Dermatol clin</term><term>Differential diagnosis</term><term>Diffuse</term><term>Diffuse hyperpigmentation</term><term>Diffuse hypopigmentation</term><term>Diffuse variant</term><term>Dirty skin color</term><term>Disorder</term><term>Durch</term><term>Early childhood</term><term>Ectodermal dysplasias</term><term>Enzyme tyrosinase</term><term>Epidermal</term><term>Evidence level</term><term>Felty syndrome</term><term>First months</term><term>First years</term><term>Genetic disorder</term><term>Genetic mosaicism</term><term>Gmbh</term><term>Hautfarbe wird vorwiegend durch</term><term>Healthy newborns</term><term>Histology</term><term>Hyperpigmentation</term><term>Hypomelanosis</term><term>Hypophyseal tumors</term><term>Hypopigmentation</term><term>Hypopigmentation results</term><term>Important factor</term><term>Inflammatory skin disease</term><term>Iris hamartomas</term><term>Jddg</term><term>Keratinocytes</term><term>Lentigo</term><term>Leopard syndrome</term><term>Lesion</term><term>Leukoderma</term><term>Lichen sclerosus</term><term>Light hair</term><term>Linea alba</term><term>Lisch nodules</term><term>Localized</term><term>Localized depigmentation</term><term>Localized hyperpigmentation</term><term>Localized hypopigmentation</term><term>Lysosomal organelles</term><term>Malassezia furfur</term><term>Mature melanosomes</term><term>Medical history</term><term>Melanin</term><term>Melanin production</term><term>Melanin synthesis</term><term>Melanocyte</term><term>Melanocytic nevi</term><term>Melanoma</term><term>Melanosomes</term><term>Mucous membranes</term><term>Neural crest</term><term>Nevus</term><term>Nevus anaemicus</term><term>Nevus depigmentosus</term><term>Nevus depigmentosus simplex</term><term>Oral mucosa</term><term>Other factors</term><term>Other organs</term><term>Piebaldism</term><term>Pigmentary changes</term><term>Pigmentation</term><term>Pigmentation disorders</term><term>Pityriasis</term><term>Pityriasis alba</term><term>Pityriasis versicolor</term><term>Porphyria</term><term>Presumptive diagnosis</term><term>Primary biliary cirrhosis</term><term>Progressive hypomelanose</term><term>Progressive macular hypomelanosis</term><term>Proximal extremities</term><term>Psychomotor retardation</term><term>Renal insufficiency</term><term>Rete ridges</term><term>Richtig</term><term>Sclerosis</term><term>Secondary body hair</term><term>Segmental vitiligo</term><term>Simplex</term><term>Skin cancer</term><term>Skin color</term><term>Stratum corneum</term><term>Syndrome</term><term>Systemic diseases</term><term>Systemic sclerosis</term><term>Tuberous</term><term>Tuberous sclerosis</term><term>Tyrosinase activity</term><term>Various ethnicities</term><term>Various organs</term><term>Various therapies</term><term>Verdachtsdiagnose eines morbus addison wird gesichert durch</term><term>Verlag</term><term>Vitiligo</term><term>Vorwiegend</term><term>Waardenburg syndrome</term><term>Welche</term><term>Welche antwort</term><term>Wird</term><term>Wood light</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Skin color is highly individual and the variations are controlled by numerous genes. The different skin colors result from the size and number of melanosomes and do not mirror the amount of melanocytes. Disorders of pigmentation can result from migration abnormalities of melanocytes from the neural crest to the skin during embryogenesis. In addition, impairment of melanosome transfer to the surrounding keratinocytes, an alteration in melanin synthesis and a defective degradation or removal of melanin may lead to abnormal skin pigmentation. Immunologic or toxic mediated destructions of melanocytes can end in pigmentation disorders. Disorders of pigmentation are classified in hypo‐ or hyperpigmentation which can occur as a genetic or acquired disease. They can manifest locally or diffuse. Congenital hypopigmentation can be restricted to the skin as in piebaldism or they represent a systemic disease as in Menkes disease or phenylketonuria. Localized hypo‐ or hyperpigmentation in children may serve as markers for systemic diseases. Ash‐leaf hypopigmentation are characteristic for tuberous sclerosis and more than 5 café‐au‐lait spots suggest neurofibromatosis 1 (von Recklinghausen disease). The most common autoimmune‐induced depigmentation is vitiligo. Generalized hyperpigmentation only rarely reflects a primary genetic disorder but is most often from acquired diseases as in Addison disease, secondary hemochromatosis or primary biliary cirrhosis. Treatment of pigmentation disorders are based on a diagnosis which sometimes allow a specific intervention. Cosmetically acceptable results are difficult to obtain.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Fistarol, Susanna K" sort="Fistarol, Susanna K" uniqKey="Fistarol S" first="Susanna K." last="Fistarol">Susanna K. Fistarol</name></noRegion><name sortKey="Itin, Peter H" sort="Itin, Peter H" uniqKey="Itin P" first="Peter H." last="Itin">Peter H. Itin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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